Next Generation Sequencing (NGS), A Key Tool to open the Personalized Medicine Era
Sun-Il Kwon
Department of Biomedical Laboratory Science, Daegu Health College, Deagu, 702-722, Korea
Correspondence to: Sun-Il Kwon
Department of Biomedical Laboratory Science, Daegu Health College, Deagu, 702-722, Korea
Tel: 053-320-1870
E-mail: psikwon@dhc.ac.kr
Department of Biomedical Laboratory Science, Daegu Health College, Deagu, 702-722, Korea
Tel: 053-320-1870
E-mail: psikwon@dhc.ac.kr
- Abstract
- Next-Generation Sequencing (NGS) is a term that means post-Sanger sequencing methods with highthroughput sequencing technologies. NGS parallelizes the sequencing process, producing thousands or millions of sequences at once. The latest NGS technologies use even single DNA molecule as a template and measures the DNA sequence directly via measuring electronic signals from the extension or degradation of DNA. NGS is making big impacts on biomedical research, molecular diagnosis and personalized medicine. The hospitals are rapidly adopting the use of NGS to help to patients understand treatment with sequencing data. As NGS equipments are getting smaller and affordable, many hospitals are in the process of setting up NGS platforms. In this review, the progress of NGS technology development and action mechanisms of representative NGS equipments of each generation were discussed. The key technological advances in the commercialized platforms were presented. As NGS platforms are a great concern in the healthcare area, the latest trend in the use of NGS and the prospect of NGS in the future in diagnosis and personalized medicine were also discussed.
- Keywords : Personalized Medicine, Next Generation Sequencing, NGS
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