Recommendations for design and implementation of PBRTQC laboratory protocols
| Subject | Recommendation |
|---|---|
| Management of PBRTQC settings | When PBRTQC is used, the appropriateness of the settings has to be guarded in a proactive manner to ensure and maintain an acceptable false alarm rate |
| PBRTQC alarm actions | PBRTQC alarm actions to be considered include: - Stop result reporting from the affected instrument - Move samples to an alternative instrument - Determine whether an analytical error occurred and, if so, determine the size of the error - Initiate troubleshooting protocol |
| PBRTQC alarm workup | PBRTQC alarm workup steps to be considered are: - Analyze internal quality control - Reanalyze recently measured samples on alternative analyzer - Run external quality control - Review recently obtained results from affected assay |
| Recovery from PBRTQC alarm | Reset/restart PBRTQC calculations after PBRTQC workup completion |
Adapted from the article of Badrick et al. (Clin Chem. 2019;65:962-971) [25] with original copyright holder’s permission.
Abbreviation: PBRTQC, patient-based real-time quality control.
