pISSN 1738-3544eISSN 2288-1662
pISSN 1738-3544eISSN 2288-1662
pISSN 1738-3544Comparison of PBRTQC and internal quality control
| Characteristic | PBRTQC | Internal quality control |
|---|---|---|
| QC frequency | Continuous | Scheduled |
| Commutability | Is commutable by design | Poses the risk of non-commutability |
| Controllable diagnostic stage | Pre-analytical and analytical stage | Analytical stage |
| QC level | One level based on patient population and moving average settings | Multiple selectable levels |
| Error detection | Bias (less frequent imprecision) | Bias and imprecision |
| Optimization | Trial and error/power functions/TEa detection simulation/ANPed/bias detection curves | Based on classical SD/σ metrics/risk |
| Validation | Power function/moving average validation charts/simulations of bias detection | Power function analysis/statistical modeling |
| Graphical presentation of the results | Accuracy plot/Levey–Jennings chart | Levey–Jennings chart |
| Use for releasing results | Ruling out results and ruling in (dependent on setup; release from the back) | Ruling out results and release of results |
| Operational costs | Considerable time during implementation for each analysis; moving average QC alarm workup | QC materials, QC analysis, and QC alarm workup |
Adapted from the article of Badrick et al. (Clin Chem. 2019;65:962-971) [25] with original copyright holder’s permission.
Abbreviations: PBRTQC, patient-based real-time quality control; QC, quality control; TEa, total error allowable; ANPed, average number of patient result error detection; SD, standard deviation.
