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Molecular Subtyping of Methicillin-Resistant Staphylococcus aureus Isolated from Patients’ Nasal Cavity
Korean J Clin Lab Sci 2020;52:128-135  
Published on June 30, 2020
Copyright © 2020 Korean Society for Clinical Laboratory Science.

Sang-Ha Kim1,2,†, Sung-Bae Park3,4,†, Heechul Park3,4, Jun Seong Kim3,4, Jungho Kim3, Jiyoung Lee3, Jaewon Lim5, Young Kwon Kim1, Sunghyun Kim3,4

1Department of Health Sciences, The Graduate School of Konyang University, Daejeon, Korea
2Department of Laboratory Medicine, Konyang University Hospital, Daejeon, Korea
3Department of Clinical Laboratory Sciences, College of Health Sciences, Catholic University of Pusan, Busan, Korea
4Clinical Trial Specialist Program for In Vitro Diagnostics, Brain Busan 21 Plus Program, The Graduate School, Catholic University of Pusan, Busan, Korea
5Department of Clinical Laboratory Science, College of Medicine and Sciences, Daegu Haany University, Kyungsan, Korea
Correspondence to: Sunghyun Kim
Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, 57 Oryundae-ro, Geumjeong-gu, Busan 46252, Korea
E-mail: shkim0423@cup.ac.kr
ORCID: https://orcid.org/0000-0003-2511-6555
The first two authors contributed equally to this work.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that causes infections in different parts of the body and causes skin and soft tissue infections (SSTI). The present study examined the antimicrobial resistance patterns and molecular epidemiological characteristics of MRSA isolated from nasal swabs in clinical patients. SCCmec type of MRSA isolates from clinical patients were analyzed: 24 cases were SCCmec type-II; two cases were type-II/IVa; one case was type-II/V; one case was type-IVa; 11 cases were not-typeable. The mec complex type of MRSA isolates from clinical patients were analyzed: 29 cases were mec complex type A, and 10 cases were not-typeable, but type B was not found in the present study. In conclusion, SCCmec type-II and mec complex type A were the most dominant MRSA subtypes among the MRSA isolates from a nasal swab of patients, and the results were similar to other studies on hospital-acquired MRSA (HA-MRSA). These results can not only provide basic data for hospital infection management but also be a good guideline for MRSA infections in the Republic of Korea.
Keywords : Infection control, Methicillin-resistant Staphylococcus aureus, Molecular epidemiology, Nasal cavity

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  • Brain Busan 21 Plus project