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Laboratory Investigation of Human Rhinovirus Infection in Cheonan, Korea
Korean J Clin Lab Sci 2019;51:329-335  
Published on September 30, 2019
Copyright © 2019 Korean Society for Clinical Laboratory Science.

Bo Kyeung Jung1, Jae Kyung Kim2

1Department of Laboratory Medicine, Dankook University Hospital, Cheonan, Korea
2Department of Biomedical Laboratory Science, Dankook University College of Health Sciences, Cheonan, Korea
Correspondence to: * Jae Kyung Kim
Department of Biomedical Laboratory Science, Dankook University College of Health Sciences, 119 Dandae-ro, Dongnan-gu, Cheonan 31116, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Annually, millions of children die from respiratory virus infections. Human rhinovirus (HRV) is a causative agent of severe respiratory infections in young, elderly, and asthmatic patients with weak immunity. In this study, 9,010 respiratory virus specimens were collected from January 2012 to December 2018 at Dankook University Hospital, Cheonan and examined by real-time reverse transcription polymerase chain reaction. Twelve respiratory viruses were detected. The mean detection rate was 21.3% (N=1,920/9,010), and the mean age of HRV-positive patients was 6.5 years (median age: 1.6 years, range: 0.0∼96.0). The detection rate was the highest in July (32.4%) and the lowest in February (8.3%). When the detection rate was analyzed by age group, the detection rate was the second highest in patients aged 10∼19 years. The co-infection rate of HRV was 35.3%, and the most common combination was with Adenovirus. Respiratory virus infections are known to occur in children and elderly people with weak immunity. However, in this study, the detection rate was second highest in patients aged 10∼19 years. Indeed, the detection rate in this age group was more than 15%, except in January and February. These results suggested that steady-state studies on the infection patterns of HRV are required.
Keywords : Human rhinovirus, Prevalence, Respiratory virus

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