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Association between Tuberculosis Case and CD44 Gene Polymorphism
Korean J Clin Lab Sci 2019;51:323-328  
Published on September 30, 2019
Copyright © 2019 Korean Society for Clinical Laboratory Science.

Hee-Seon Lim, Sang-In Lee, Sangjung Park

Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, Asan, Korea
Correspondence to: * Sangjung Park
Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, 20 Hoseo-ro 79beon-gil, Asan 31499, Korea
E-mail: sangjung@hoseo.edu
* ORCID: https://orcid.org/0000-0003-4240-4612
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Tuberculosis, a chronic bacterial infection caused by Mycobacterium tuberculosis (MTB), differs in its status latency and activity because of the characteristics of MTB, immune status of the host, and genetic susceptibility. The host defense mechanism against MTB is caused mainly by interactions between macrophages, T cells, and dendritic cells. CD44 is expressed in activated T cells when infected with MTB and regulates lymphocyte migration. In addition, CD44 mediates leukocyte adhesion to the ECM and plays a role in attracting macrophages and CD4+ T cells to the lungs. Therefore, genetic polymorphism of the CD44 gene will inhibit the host cell immune mechanisms against MTB. This study examined whether the genetic polymorphism of the CD44 gene affects the susceptibility of tuberculosis. A total of 237 SNPs corresponding to the CD44 genes were analyzed using the genotype data of 443 tuberculosis cases and 3,228 healthy controls from the Korean Association Resource (KARE). Of these, 17 SNPs showed a significant association with the tuberculosis case. The most significant SNP was rs75137824 (OR=0.231, CI: 1.51∼3.56, P=1.3×10‒4). In addition, rs10488809, one of the 17 significant SNPs, is important for the tuberculosis outbreak can bind to the JUND and FOS transcription factors and can affect CD44 gene expression. This study suggests that polymorphism of the CD44 gene modulates the host susceptibility to tuberculosis in a variety of ways, resulting in differences in the status of tuberculosis.
Keywords : CD44, Genetic association study, Mycobacterium tuberculosis, SNP, Tuberculosis

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