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Study on Correlation between Cognitive Impairment and Geriatric Depression or Geriatric Stress
Korean J Clin Lab Sci 2019;51:105-113  
Published on March 31, 2019
Copyright © 2019 Korean Society for Clinical Laboratory Science.

Dae Jin Kim1,†, Soo-Young Cho2,†, Jeong Su Choi3, Min Woo Lee4, Eun-Kyung Cho5, Se-hee Kang2,6,Suhng Wook Kim6

1Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Korea 2Department of Neurology, Seoul National University Hospital, Seoul, Korea 3Department of Integrated Biomedical and Life Sciences, Graduate School, Korea University, Seoul, Korea 4Institute of Health Science, College of Health Science, Korea University, Seoul, Korea 5Department of Laboratory Medicine, Graduate School of Medicine, Kangwon National University, Chuncheon, Korea 6Department of Health and Safety Convergence Science, Graduate School, Korea University, Seoul, Korea
Correspondence to: Suhng Wook Kim
Department of Health and Safety Convergence Science, Graduate School, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea, Tel: 82-2-3290-5686, Fax: 82-2-940-2829, E-mail:, ORCID:
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This study examined the effects of geriatric depression and geriatric stress on cognitive impairment. In particular, the dementia groups were divided into Alzheimer’s disease and vascular dementia. A normal group was used as the control group. For each group, the geriatric depression using the geriatric depression scale (GDS) and geriatric stress using the geriatric stress scale (GSS) was compared with the regression and correlation results of cognitive impairment. Statistical tests, such as descriptive statistics, Kruskall-Wallis, correlation analysis, and multiple regression analysis, were performed. For the Alzheimer’s group, the GDS and GSS correlated with the cognitive impairment, but only the GDS showed a cause-and-effect relationship with cognitive impairment. In particular, the male group with Alzheimer’s disease showed clear confirmation. In addition, geriatric stress was found to be associated with geriatric depression. In conclusion, geriatric depression affects the cognitive impairment directly and geriatric stress affects the cognitive ability indirectly through geriatric depression. In this study, the Alzheimer’s disease, vascular dementia, and control groups had a small sample size. Therefore, the external validity in future studies can be increased using a larger sample size for each group.
Keywords : Alzheimer’s disease, Cognitive impairment, Geriatric depression, Geriatric stress, Vascular dementia

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