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Relationships of the Vitamin D and Platelet Indices inSjögren’s Syndrome
Korean J Clin Lab Sci 2018;50:484-491  
Published on December 31, 2018
Copyright © 2018 Korean Society for Clinical Laboratory Science.

Nahide Ekici Günay1, İrfan Buğday2, Tayfun Akalın3

1Department of Clinical Biochemistry, University of Health Science, Kayseri City Training and Research Hospital, Turkey 2Department of General Medicine, University of Health Science, Yeşilhisar State Hospital, Kayseri, Turkey 3Department of General Medicine, Division of Rheumatology, University of Health Science, Kayseri City Training and Research Hospital, Turkey
Correspondence to: Nahide Ekici Günay
Department of Clinical Biochemistry, University of Health Science, Kayseri City Training and Research Hospital, Şeker Mah. Molu Cad. 38080, Turkey
Tel: 90-352-315-77-00 Fax: 90-352-336-88-57 E-mail: edihan30@yahoo.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Primer Sjögren's Syndrome (pSS) is an autoimmune/inflammatory illness. The platelet indices (PIs) indicate the inflammatory response and activity/severity of many diseases. A vitamin D deficiency is accompanied by the increased tendency of autoimmune diseases. This study investigated whether the vitamin D levels are related to the altered platelet indices in pSS. A total of 261 individuals were included in this analytical cross-sectional study. The laboratory data of pSS patients were evaluated and the relationship between the PIs and vitamin D status was examined. According to these findings, in patients with pSS, the vitamin D levels were lower than the healthy control group (P<0.05). The vitamin D levels were negatively associated with PDW (P=0.012), but positively correlated with PCT (P<0.001). The cut-off point was obtained with receiver operating characteristics (ROC) curves for PDW: 12.53 (AUC 0.921, sensitivity 90%,specificity 85%), for PCT; 0.29 (AUC 0.660, sensitivity 68%, specificity 55%). In multivariate linear regression analysis, the most significant parameters for the effects of PDW are the following: vitamin D (β=−0.373; t=−2.626; sig.=0.013) and plateletcrit (β=−0.308; t=−2.13; sig.=0.040). A vitamin D deficiency may be accompanied by changes in PIs in pSS. A higher PDW and lower PCT supports the underlying inflammation, which may be vitamin D related useful parameters to consider in approaching to pSS.
Keywords : Plateletcrit, Platelet distribution width, Sjögren’s syndrome, Vitamin D

December 2018, 50 (4)
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