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Overview of Cytogenetic Technologies
Korean J Clin Lab Sci 2018;50:375-381  
Published on December 31, 2018
Copyright © 2018 Korean Society for Clinical Laboratory Science.

Ji-Un Kang

Department of Biomedical Laboratory Science, Korea Nazarene University, Cheonan, Korea
Correspondence to: Ji-Un Kang
Department of Biomedical Laboratory Science, Korea Nazarene University, 48 Weolbong-ro, Seobuk-gu, Cheonan 31172, Korea
Tel: 82-41-570-4164 Fax: 82-41-570-4128 E-mail: jukang@kornu.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Cytogenetic analysis plays an important role in examinations of a variety of human disorders. Over the years, cytogenetic analysis has evolved to a great extent and become a part of routine laboratory testing; the analysis provides significant diagnostic and prognostic results for human diseases. Microarray in conjunction with molecular cytogenetics and conventional chromosome analysis has transformed the outcomes of clinical cytogenetics. The advantages of microarray technologies have become obvious to the medical and laboratory community involved in genetic diagnosis, resulting in greatly improved visualization and validation capabilities. This article reviews how the field is moving away from conventional cytogenetics towards molecular approaches for the identification of pathogenic genomic imbalances and discusses practical considerations for the routine implementation of these technologies in genetic diagnosis
Keywords : Conventional cytogenetics, Microarray technologies, Molecular cytogenetics

December 2018, 50 (4)
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