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Genetic Variations of Candida albicans Isolated from Clinical Specimens Using Multi-locus Sequence Typing Analysis
Korean J Clin Lab Sci 2018;50:331-336  
Published on September 30, 2018
Copyright © 2018 Korean Society for Clinical Laboratory Science.

Hee-Jin Kim1,†, Sang-Ha Kim2,†, Sunghyun Kim3, Young-Bin Yu4, Young-Kwon Kim4

1Department of Laboratory Medicine, Sun General Hospital, Daejeon, Korea
2Department of Laboratory Medicine, Konyang University Hospital, Daejeon, Korea
3Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan, Korea
4Department of Biomedical Laboratory Science, College of Medical Sciences, Konyang University, Daejeon, Korea
Correspondence to: Young-Kwon Kim
Department of Biomedical Laboratory Science, College of Medical Sciences, Konyang University, 158 Gwanjeodong-ro, Seo-gu, Daejeon 35365, Korea
Tel: 82-42-660-6371
Fax: 82-42-543-6370
E-mail: ykkim3245@konyang.ac.kr
The first two authors contributed equally to this work.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
In this study, multi-locus sequence typing (MLST) analysis of 40 clinically isolated Candida albicans in tertiary hospitals in Daejeon, Korea, confirmed the nucleotide sequence and phylogenetic relationships of the strains collected from different specimen sources. The general variations found in seven different housekeeping genes of C. albicans, collected from urine and sputum, peripheral blood, central line blood, and other specimens, were analyzed. The phylogenetic tree was divided into 18 sub-clusters (1), a central line blood (2), others (5), sputum (1), peripheral blood (6), sputum (1), and urine (1), and the isolates at the same site were confirmed to have genetic similarity. Consequently, genetic similarity and the potential relevance were found in the strains collected from the same specimen sources. MLST analysis of C. albicans suggests that persistent data accumulation of phylogenetic gene variations of C. albicans may help establish infectious disease studies and epidemiological surveillance systems.
Keywords : Clinical specimens, Candida albicans, Genetic variation, MLST analysis

September 2018, 50 (3)
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