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Correlation between Serum Osteocalcin and Hemoglobin A1c in Gwangju General Hospital Patients
Korean J Clin Lab Sci 2018;50:313-319  
Published on September 30, 2018
Copyright © 2018 Korean Society for Clinical Laboratory Science.

Yo-Han Seo1, Hee-Young Shin2

1Department of Laboratory Medicine, Gwangju Veterans Hospital, Gwangju, Korea
2Department of Biomedical Science, Chonnam National University Medical School, Gwangju, Korea
Correspondence to: Hee-Young Shin
Department of Biomedical Science, Chonnam National University Medical School, 322 Seoyang-ro, Hwasun-eup, Hwasun-gun, Jeonnam 58128, Korea
Tel: 82-61-379-2675
Fax: 82-61-379-2650
E-mail: hyshin@jnu.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Recently, there have been many studies on the relationship between the bone metabolism and the mechanism of diabetes. In those studies, it was shown that osteocalcin can be involved in the treatment of type 2 diabetes. Therefore, this study examined the correlation between osteocalcin and HbA1c. From January 1, 2015 to December 31, 2016, a total of 714 adults aged 40 years or older (70.8±10.4 years, 452 males), in whom both osteocalcin and HbA1c checked in a general hospital in Gwangju, were enrolled in the study. The serum calcium, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, and 25-(OH) vitamin D were measured and basic information, such as the height and weight, were recorded. There was a weak negative correlation (r=-0.183, P<0.001) between the osteocalcin and HbA1c levels in diabetic patients but a negative correlation (r=-0.251, P<0.001) when adjusted by all other study variables. The present study showed that there was a negative correlation between the osteocalcin and HbA1c levels in diabetic patients. The relationship between the bone metabolism and the incidence of diabetes mellitus should be studied based on the influence of biological mechanisms and associated factors of bone and glucose metabolism.
Keywords : Bone, Diabetes mellitus, Hemoglobin A1c, Osteocalcin

September 2018, 50 (3)
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