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Anti-Xanthine Oxidase, Anti-Cholinesterase, and Anti-Inflammatory Activities of Fruiting Bodies of Phellinus gilvus
Korean J Clin Lab Sci 2018;50:225-235  
Published on September 30, 2018
Copyright © 2018 Korean Society for Clinical Laboratory Science.

Ki Nam Yoon, Hyung Seok Jang

Department of Clinical Laboratory Science, Ansan University, Ansan, Korea
Correspondence to: Ki Nam Yoon
Department of Clinical Laboratory Science, Ansan University, 155 Ansandaehak-ro, Sangnok-gu, Ansan 15328, Korea
Tel: 82-31-400-7068
Fax: 82-31-363-7702
E-mail: kinam@ansan.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Phellinus gilvus is a medicinal mushroom used that has been used in folk medicine in Asian countries for centuries. The aim of this study was to investigate the anti-xanthine oxidase, anti-cholinesterase, and anti-inflammatory activities of methanol (ME) and hot water (HW) extracts prepared from fruiting bodies of Ph. gilvus. ME and HW had good anti-xanthine oxidase (XO) activities compared to allopurinol, an inhibitor of xanthine oxidase. ME showed comparable and slightly lower inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively, than galanthamine, a standard AChE and BChE inhibitor. ME also showed a protective effect against glutamate-induced cytotoxicity at 40 mg/mL and 100 mg/mL in PC-12 cells. ME (0.5∼2.0 mg/mL) significantly inhibited nitric oxide (NO) production in RAW 264.7 murine macrophage cells stimulated with lipopolysaccharide (LPS). Carrageenan-induced hind-paw edema in rats was significantly reduced 2∼6 hr after treatment with 50 mg/kg of ME, which was comparable to administration of 5 mg/kg of indomethacin, the positive control. These results demonstrate that ME and HW of Ph. gilvus fruiting bodies possess good anti-xanthine oxidase, anti-cholinesterase, and anti-inflammatory activities.
Keywords : Anti-inflammation, Anti-xanthine oxidase, Cholinesterase inhibitors, Phellinus gilvus

September 2018, 50 (3)
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