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Histological Evaluation of Bioresorbable Threads in Rats
Korean J Clin Lab Sci 2018;50:217-224  
Published on September 30, 2018
Copyright © 2018 Korean Society for Clinical Laboratory Science.

Chang Gun Lee1, Jaeyun Jung2, Samnoh Hwang3, Chan Oh Park1, Soonjae Hwang1, Minjeong Jo1, Min Hi Sin4, Hyun Ho Kim5, Ki-Jong Rhee1

1Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University, Wonju, Korea
2Mielle Dermatology & Plastic Surgery Network Clinic, Busan, Korea
3Department of Pathology, The Catholic University of Korea, Seoul Saint Mary’s Hospital, Seoul, Korea
4Department of Pathology, Wonju Severance Christian Hospital, Wonju, Korea
5 NEO Dr. Inc., Wonju, Korea
Correspondence to: Ki-Jong Rhee
Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University, 1 Yonseidae-gil, Wonju 26493, Korea
Tel: 82-33-760-2445
Fax: 82-33-760-2195
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Thread lifting has become popular as a minimally invasive technique for facial rejuvenation. Commercially available threads are composed of poly-L-lactic acid (PLLA), polycaprolactone (PCL), or polydioxanone (PDO). However, the histological changes that occur in response to implanted threads are unclear. The aim of this study was to evaluate histological changes that occur in response to implantation with three types of bioresorbable threads (PLLA, PCL, PDO) in rat skin. PLLA, PCL and PDO threads were implanted in the dorsal skin of Sprague Dawley rats and tissue samples were harvested 2, 4, 8 and 12 weeks post-implantation. To evaluate histologic changes induced by bioresorbable face-lifting threads, tissue samples were stained with hematoxylin & eosin, Masson’s trichrome stain and Herovici’s collagen stain. All three threads induced neocollagenesis of type 3 collagen in the rat skin. The amount of collagen induced by the threads was dependent on the thread surface area. The PDO cavern-type thread was most effective in inducing neocollagenesis due to its extensive surface area. Our results suggest that type 3 collagen induced by bioresorbable threads depends on the thread surface area to uphold the dermis and contributes to facial rejuvenation.
Keywords : Collagen, Polydioxanone, Rat, Skin

September 2018, 50 (3)
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