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Inhibitory Effects of Zerumbone on MCP-1-Induced THP-1 Migration
Korean J Clin Lab Sci 2018;50:177-182  
Published on June 30, 2018
Copyright © 2018 Korean Society for Clinical Laboratory Science.

Sa Hyun Kim1, Si Hyun Kim1, Sung Ryul Ryu1, Pyeongjae Lee2, Cheol Moon1

1Department of Clinical Laboratory Science, Semyung University, Jecheon, Korea
2Department of Natural Medicine Resources, Semyung University, Jecheon, Korea
Correspondence to: Cheol Moon
Department of Clinical Laboratory Science, Semyung University, 65 Semyung-ro, Jecheon 27136, Korea Tel: 82-43-649-1419 Fax: 82-43-649-1419 E-mail: antigene@semyung.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
This study examined the effects of zerumbone on monocyte migration. Monocytes are recognized as important mediators of various inflammatory diseases, and the possibility of controlling inflammatory diseases by regulating the monocyte functions, such as activity and mobility, has been reported. MCP-1, which is a chemokine with levels that increase upon inflammation, causes the migration of the monocyte cell line, THP-1. Migration occurred at a concentration of 10 ng/mL MCP-1, and the highest migration occurred at 100 ng/mL and 200 ng/mL. MCP-1-induced THP-1 migration decreased by more than 40% in the presence of zerumbone. The concentration of cAMP, an important secondary messenger of the CCR2 signaling pathway, the MCP-1 receptor, was increased in the culture medium after a zerumbone treatment. The concentrations of cAMP decreased significantly under the MCP-1 treatment condition only. On the other hand, an increase in cAMP was observed when zerumbone and MCP-1 were treated simultaneously. Erk phosphorylation induced by an MCP-1 treatment was also found to decrease with the zerumbone treatment. This study introduces the possibility of controlling inflammatory diseases through the function of zerumbone, which regulates the migration of monocytes.
Keywords : Migration, Monocyte, Monocyte chemoattractant protein 1, Zerumbone

June 2018, 50 (2)
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