Association between ITGB2 Genetic Polymorphisms and Tuberculosis
Hyun-Seok Jin, Sang-In Lee, Sangjung Park
Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, Asan, Korea
Correspondence to: Sangjung Park
Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, 20 Hoseo-ro 79 Beon-gil , Asan 31499, Korea Tel: 82-41-540-9967 Fax: 82-41-540-9997 E-mail: sangjung@hoseo.edu
Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, 20 Hoseo-ro 79 Beon-gil , Asan 31499, Korea Tel: 82-41-540-9967 Fax: 82-41-540-9997 E-mail: sangjung@hoseo.edu
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Abstract
- Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB), but the genes associated with the host immune system can be attributed to the development of TB. The ITGB2 gene encodes the integrin beta 2 chain CD18 protein and is present on chromosome 21. The integrin beta 2 chain is an integrin expressed in leukocytes and plays a very important role in leukocyte maturation and attachment. ITGB2 plays an important role in the phagocytosis of MTB and the aggregation of leukocytes in MTB infections. This study examined the genetic polymorphisms of the ITGB2 gene between the TB case and normal control using Korean genomic and epidemiologic data. As a result, a statistically significant correlation was confirmed in 10 SNPs. The most significant SNP was rs113421921 (OR=0.69, CI: 0.53∼0.90, P=5.8×10−3). In addition, rs173098, one of the significant 10 SNPs, is possibly located in a binding motif with the transcription factor cofactor p300, and can affect ITGB2 gene expression. These findings suggest that the pathogenesis of TB may be influenced by a range of genetic factors related to the immune function of the host, e.g., the reactions associated with the recruitment and attachment of leukocytes. The results of this study could be used to predict the infection control for tuberculosis in a patient-tailored manner.
- Keywords : CD18, Genetic association study, ITGB2, Mycobacterium tuberculosis, SNP
- June 2018, 50 (2)
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Funding Information-
- National Research Foundation of Korea(NRF)
10.13039/501100003725
- Ministry of Science, ICT and Future Planning(MSIP)
10.13039/501100003621
2017R1C1B5016589
