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Effects of Green Tea Catechins (GTC) on the Treatment of Hangover and Prevention of Liver Disease
Korean J Clin Lab Sci 2014,46:131-135  
Published on December 31, 2014
Copyright © 2014 Korean Society for Clinical Laboratory Science.

Mi-Yea Lee1, Won Shik Kim2 and Yong Lim3

1Department of Nursing, Chungbuk Health&Science University, Cheongwon 363-794, Korea
2Department of Clinical Laboratory Science, Daejeon Health Sciences College, Daejeon 300-711, Korea
3Department of Clinical Laboratory Science, Dong-Eui University, Busan 614-714, Korea
Correspondence to: Yong Lim
Department of Clinical Laboratory Science, Dong-eui University, 176 Eomgwang-ro, Busanjin-gu, Busan 614-714, Korea
E-mail: yonglim@deu.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Over-consumption of alcohol leads to many side-effects such as malnutrition, liver disease, and neuronal disorders and many investigators have tried to identify methods for preventing the side-effects of drinking. This study was carried out to investigate the effect of the beverage contained green tea catechins (GTC) on the alcohol administered rats. We observed that blood alcohol concentration level decreased significantly in plasma. GTC (200 mg/kg) also reduced the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) level of the intoxicated rats. These results suggest that GTC may be useful for the prevention and therapy of hepatotoxic pathogenesis.
Keywords : Alcohol, GTC, AST, ALT
References
  1. Choi HB. Alcoholic liver disease. Korean J Gastroenterol 2009, 53:275-282.
    CrossRef
  2. An SW, Kim YG, Kim MH, Lee BI, Lee SH, Lwon HI, Hwang B, Lee HY. Comparison of hepatic detoxification activity and reducing serum alcohol concentration of Hovenia dulsis THUNB and Alnus japonica Steud. J Medicinal Crop Sci. 1999, 7:263268.
  3. Hawkins RD, Kalant H. The metabolism of ethanol and its metabolic effects. Pharmacol Rev. 1972, 24:67-157.
    Pubmed
  4. Lim RC, Li TK. Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. Am J Clin Nutr. 1998, 68:1512S-1515S.
  5. Forsander OA and Raiha Niels CR. Metabolites produced in the liver during alcohol oxidation. J Biol Chem. 1960, 235:34-36.
    Pubmed
  6. Wheeler MD, Nakagami M, Bradford BU, Uesugi T, Mason RP, Connor HD, Dikalova A, Kadiiska M, Thurman RG. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. J Biol Chem. 2001, 276:36664-36672.
    Pubmed CrossRef
  7. Abdellah M, Demelliers C, Amsellem S, Pessayre D, Fromenty B. Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants. J Pharmacol Exp Ther. 2001, 298:737-743.
  8. Kim JS. Effect of a alcohol detoxification beverage (ADB) contained Radix puerariae and Bambusae caules in Liquamen Phyllostachyos on the alcohol administered mouse. J Korean Soc Food Sci Nutr. 2004, 33:318-323.
    CrossRef
  9. Lim Y. The protective effects of green tea catechin on the blomycin and cyclophosphamide induced cytotoxicity. Koean J Clin Lab Sci. 2014, 46:75-78.
    CrossRef
  10. Wang JY, Shum AY, Hwang CP. Ethanol modulates induction of nitric oxide synthase in glial cells by endotoxin. Life Science. 1998, 63:1571-1583.
    CrossRef
  11. Plaa GL and Charbonneau M. Detection and evalution of chemically induced liver injury: In Hayes, A.W. (ed.) Principles and methods of toxicology. 3rd ed., Raven press, New York. 1994.
  12. Forsander OA, Raiha Niels CR. Metabolites produced in the liver during alcohol oxidation. J Biol Chem. 1960, 235:34-36.
    Pubmed
  13. Hawkins RD, Kalant H. The metabolism of ethanol and its metabolic effects. Pharmacol Rev. 1972, 24:67-157.
    Pubmed