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Anti-Obesitic Effect of Mulberry Root-Bark (Mori radicis Cortex) in Zucker Rats with High Lipid Diet Induced-Obesity
Korean J Clin Lab Sci 2005,37:129-137  
Published on August 31, 2005
Copyright © 2005 Korean Society for Clinical Laboratory Science.

Seong-Hee Hong, Dong-Kyu Kim, Nam-Jin Lee, Jung-Hee Cho, Jong-Koo Kang, Yun-Bae Kim, Jung-Hui Park, and Seock-Yeon Hwang

College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea1
Park Jung-Hui Oriental Medical Clinic, Daejeon 302-122, Korea2
Department of Laboratory Medicine, Chungbuk National University Hospital, Cheongju 360-240, Korea3

Correspondence to: 황석연
(우)361-713 충북 청주시 개신동 62, 충북대학교병원 진단검사의학과
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This study was performed to investigate the anti-obesitic effect of mulberry root-bark on male and female Zucker FA/FA or FA/fa rats. Obesity in the rats was induced by feeding high-lipid diet contained 3% corn oil and 1% cholesterol. Experimental groups in male and female rats were assigned to normal diet group (normal control), high-lipid diet group(positive control) and 3% mulberry root-bark powder in high-lipid diet group (MRC). The mulberry treated-group showed decreases of body weight, FER (food efficiency ratio) value and lipid peroxidation in the liver and increase of high density lipoprotein cholesterol (HDL-C) value, compared with positive control groups. Our findings suggest that mulberry root-bark has a potential role in preventing or improving obesity from the following points of view, body weight, serum lipids and antioxidant enzyme activities.
Keywords : Zucker rats, Mulberry root, Anti-obesity

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