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MACROD2 Polymorphisms Are Associated with Hypertension in Korean Population
Korean J Clin Lab Sci 2019;51:57-63  
Published on March 31, 2019
Copyright © 2019 Korean Society for Clinical Laboratory Science.

Bokyung Ko, Hyun-Seok Jin

Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, Asan, Korea
Correspondence to: Hyun-Seok Jin
Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, 20 Hoseo-ro 79 Beon-gil, Asan 31499, Korea, Tel: 82-41-540-9968, Fax: 82-41-540-9997, E-mail: jinhs@hoseo.edu, ORCID: https://orcid.org/0000-0002-3673-9806
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Hypertension is caused by a combination of genetic and environmental factors. In advanced countries, more than 30% of adults have hypertension. Among the genetic factors affecting hypertension, there are reports from European cohort studies that variants of the MACROD2 gene are correlated with blood pressure and the hypertension status. In this study, genetic polymorphisms of the MACROD2 gene region were selected and extracted based on Korean Genome and Epidemiology data, and logistic regression analysis was then performed for the hypertensive state. Linear regression analysis was also performed for the systolic and diastolic blood pressure. As a result, 16 SNPs showed a statistically significant association with a hypertensive state, and 2 SNPs (rs16996211, rs6034240) showed statistical significance, even in blood pressure. The most significant rs16996211 had a relative risk of hypertension of 0.85 (CI: 0.76∼0.95, P=3.1×10?3), as well as an association with the systolic blood pressure (beta=?0.75, P=0.024) and diastolic blood pressure (beta=?0.59, P=0.01). These results suggest that polymorphisms of the MACROD2 gene are associated with hypertension in both Caucasians and Koreans, and highlight the potential genetic correlations with the pathogenesis of hypertension.
Keywords : Association, Blood pressure, Hypertension, MACROD2, SNP


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