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Diagnostic Availability of Estrogen Receptor Alpha mRNA on Cervical Cancer Tissue
Korean J Clin Lab Sci 2018;50:449-456  
Published on December 31, 2018
Copyright © 2018 Korean Society for Clinical Laboratory Science.

Geehyuk Kim1, Kwangmin Yu1, Jungho Kim1, Seoyong Kim1, Sunyoung Park1, Sungwoo Ahn1, Ji-Young Lee1, Sunghyun Kim2, Ho-Hyun Park3, Dongsup Lee4

1Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University, Wonju, Korea 2Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Pusan, Korea 3Department of Biomedical Laboratory Science, Mokpo Science University, Mokpo, Korea 4Department of Clinical Laboratory Science, Hyejeon College, Hongseong, Korea
Correspondence to: Dongsup Lee
Department of Clinical Laboratory Science, Hyejeon College, 25 Daehak-gil, Hongseong 32244, Korea
Tel: 82-41-630-5342 Fax: 82-41-630-5364 E-mail: eastern3547@naver.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Cervical cancer is the fourth most frequently diagnosed cancer in women worldwide. In lower Human Development Index countries, it has the second highest incidence and mortality among cancer in women. Therefore, better diagnosis and treatment systems are needed. Among them, estrogen receptor alpha (ER-α) mRNA expression has been analyzed with RT-qPCR since several studies reported that ER-α is necessary in the maturation of the uterus and is related to cervical cancer. In this study, ER-α quantitative analysis was performed on various lesions and normal tissue samples. Based on the receiver operating characteristic (ROC) curve, its sensitivity and specificity were 85% and 75%, respectively, showing higher or similar results to those of conventional HPV tests. In addition, its expression level was analyzed with clinical information. With regression analysis, the R square value between the ER-α mRNA expression level and menopause status was 0.5041, indicating a strong correlation. This study was performed as part of a pilot study and suggests that ER-α is related to carcinogenesis. Future studies will examine other hormones and menopausal factors with a larger sample size.
Keywords : Age, Cervical cancer, Estrogen receptor alpha, Formalin-fixed paraffin-embedded tissue, Menopause


December 2018, 50 (4)
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