search for   


Effects of Scutellaria scordifolia Fisch. ex Schrank Extracts on Biofilm Formation and the Activities of Klebsiella pneumoniae
Korean J Clin Lab Sci 2018;50:438-443  
Published on December 31, 2018
Copyright © 2018 Korean Society for Clinical Laboratory Science.

Keun-Dol Yook1, Nayoung Ha2

1Department of Clinical Laboratory Science, Daejeon Health Institute of Technology, Daejeon, Korea 2Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, California, USA
Correspondence to: Keun-Dol Yook
Department of Clinical Laboratory Science, Daejeon Health Institute of Technology, 21 Chungjeong-ro, Dong-gu, Daejeon 34504, Korea
Tel: 82-42-670-9169 Fax: 82-42-670-9582 E-mail:
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The emergence of biofilms have generated urgent alarm in clinical and medicine manufacturing fields engaged in the search for novel antimicrobials from ethno-medicinal plants. The National Institutes of Health (NIH) has estimated that 70% of all microbial infections in the world are associated with biofilms. In addition, the emergence of strains resistant to conventional antibiotics has become a serious threat to global public health. Therefore, finding alternative medicines is a major issue in the field of integrative medicine. In this study, four different herb extracts were screened for biofilm formation and the activities of Klebsiella pneumoniae. Of them, Scutellaria scordifolia Fisch. ex Schrank extracts had inhibitory effects on bacterial growth and biofilm formation. The Scutellaia scordifolia Fisch. ex Schrank extracts did not cause any cytotoxicity to L929 cells. The growth of K. pneumoniae was inhibited compared to other comparators in the experimental group containing Scutellaia scordifolia Fisch. ex Schrank. In a group of experiments with plant extracts, a maximum of 60 times the level of living bacteria was confirmed compared to the controls without the addition of the Scutellaia scordifolia Fisch. ex Schrank extracts. In a group of experiments with a significantly lower level of fluorescence extraction, differential interference contrast imaging showed that the number of K. pneumonae was reduced. These results suggest that extracts of this plant be applied as antimicrobial agents against K. pneumoniae, particularly in biofilm forms.
Keywords : Alternative medicine, Biofilm, Plant extracts

December 2018, 50 (4)
Full Text(PDF) Free

Cited By Articles
  • CrossRef (0)