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Mesenchymal Stem Cell-derived Exosomes: Applications in Cell-free Therapy
Korean J Clin Lab Sci 2018;50:391-398  
Published on December 31, 2018
Copyright © 2018 Korean Society for Clinical Laboratory Science.

June Seok Heo1, Jinkwan Kim2

1Department of Clinical Laboratory Science, Ansan University, Ansan, Korea
2Department of Laboratory Medicine, Korea University Medical Center, Ansan Hospital, Ansan, Korea
Correspondence to: Jinkwan Kim
Department of Biomedical Laboratory Science, College of Health Science, Jungwon University, 85 Munmu-ro, Goesan-eup, Goesan-gun, Goesan 28024, Korea
Tel: 82-43-830-8860 Fax: 82-43-830-8115 E-mail: jkkim@jwu.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Mesenchymal stem cells (MSCs) are an attractive resource for refractory patients because of their anti-inflammatory/immunomodulatory capability and multi-lineage differentiation potential. The transplantation of MSCs has led to positive results in preclinical and clinical application to various diseases, including autoimmune disease, cardiovascular disease, cancer, liver cirrhosis, and ischemic stroke. On the other hand, studies have shown that paracrine factors, not direct cell replacement for damaged cells or tissue, are the main contributors in MSC-based therapy. More recently, evidence has indicated that MSC-derived exosomes play crucial roles in regulating the paracrine factors that can mediate tissue regeneration via transferring nucleic acids, proteins, and lipids to the local microenvironment and cell-to-cell communication. The use of these exosomes is likely to be beneficial for the therapeutic application of MSCs because their use can avoid harmful effects, such as tumor formation involved in cell transplantation. Therefore, therapeutic applications using MSC-derived exosomes might be safe and efficient strategies for regenerative medicine and tissue engineering. This review summarizes the recent advances and provides a comprehensive understanding of the role of MSC-derived exosomes as a therapeutic agent.
Keywords : Exosome, Mesenchymal stem cell, Stem cell, Therapy


December 2018, 50 (4)
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