Target gene lists
| Target genes | |
|---|---|
| Hotspot genes | AKT1, AKT2, AKT3, ALK, AR, ARAF, ARID1A, ATM, ATR, ATRX, AXL, BAP1, BRAF, BRCA1, BRCA2, BTK, CBL, CCND1, CCND2, CCND3, CCNE1, CDK12, CDK2, CDK4, CDK6, CDKN1B, CDKN2A, CDKN2B, CHEK1, CHEK2, CREBBP, CSF1R, CTNNB1, DDR2, EGFR, ERBB2, ERBB3, ERBB4, ERCC2, ESR1, EZH2, FANCA, FANCD2, FANCI, FBXW7, FGF19, FGF3, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, FOXL2, GATA2, GNA11, GNAQ, GNAS, H3F3A, HIST1H3B, HNF1A,HRAS, IDH1, IDH2, IGF1R, JAK1, JAK2, JAK3, KDR, KIT, KNSTRN, KRAS, MAGOH, MAP2K1, MAP2K2, MAP2K4, MAPK1, MAX, MDM2, MDM4, MED12, MET, MLH1, MRE11A, MSH2, MSH6, MTOR, MYC, MYCL, MYCN, MYD88, NBN, NF1, NF2, NFE2L2, NOTCH1, NOTCH2, NOTCH3, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3R1, PMS2, POLE, PPARG, PPP2R1A, PTCH1, PTEN, PTPN11, RAC1, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAF1, RB1, RET, RHEB, RHOA, RICTOR, RNF43, ROS1, SETD2, SF3B1, SLX4, SMAD4, SMARCA4, SMARCB1, SMO, SPOP, SRC, STAT3, STK11, TERT, TOP1, TP53, TSC1, TSC2U2AF1, XPO1 |
| Full-length genes (tumor suppressor gene) | ATM, BAP1, BRCA1, BRCA2, CDKN2A, FBXW7, MSH2, NF1, NF2, NOTCH1, PIK3R1, PTCH1, PTEN, RB1, SMARCB1, STK11, TP53, TSC1, TSC2, ARID1A, ATR, ATRX, CDK12, CDKN1B, CDKN2B, CHEK1, CREBBP, FANCA, FANCD2, FANCI, MLH1, MRE11A, MSH6, NBN, NOTCH2, NOTCH3, PALB2, PMS2, POLE, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RNF43, SETD2, SLX4, SMARCA4 |
| Copy number genes | ALK, AXL, BRAF, EGFR, ERBB2, ERG, ETV1, ETV4, ETV5, FGFR1, FGFR2, FGFR3, NTRK1, NTRK3, PDGFRA, PPARG, RAF1,R ET, ROS1, AKT2, AR, BRCA1, BRCA2, CDKN2A, ERB84, ESR1, FGR, FLT3, JAK2, KRAS, MDM4, MET, MYB, MYBL1, NF1, NOTCH1, NOTCH4, NRG1, NTRK2, NUTM1, PDGFRB, PIK3CA, PRKACA, PRKACB, PTEN, RAD51B, RB1, RELA, RSPO2, RSPO3, TERT |
| Fusion driver genes | ALK, AXL, BRAF, EGFR, ERBB2, ERG, ETV1, ETV4, ETV5, FGFR1, FGFR2, FGFR3, NTRK1, NTRK3, PDGFRA, PPARG, RAF1,R ET, ROS1, AKT2, AR, BRCA1, BRCA2, CDKN2A, ERB84, ESR1, FGR, FLT3, JAK2, KRAS, MDM4, MET, MYB, MYBL1, NF1, NOTCH1, NOTCH4, NRG1, NTRK2, NUTM1, PDGFRB, PIK3CA, PRKACA, PRKACB, PTEN, RAD51B, RB1, RELA, RSPO2, RSPO3, TERT |
Target gene sequencing: ion torrent S5 (540 chip kit). Variant detection, interpretation: ion reporter V5.6, oncomine reporter; Reference sequence: GRCh37/hg19.
