Result of FISH-ROS1 test in lung adenocarcinoma tissue (1,000×). (A) Nuclei of tumor cells stained with DAPI. (B) Green signal detected through green filter. (C) Orange signal detected through green filter. (D) The result of merged the two signals. Red circles: ROS1-positive signal (split signal and single green signal). Yellow circles: ROS1 negative signal (green/orange fusion signal and single orange signal). Abbreviation: ROS1: receptor tyrosine kinase 1; FISH, fluorescence in situ hybridization; DAPI, 4′,6-diamidino-2-phenylindole.
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