Fig. 4. Protein-protein interaction (PPI) network analyses using the STRING database for the DEGs expressed in the cancer cells. (A) PPI between the DEGs up-regulated by MNNG-treatment, of which expression also increased in the cancer cells. (B) PPIs between the DEGs down-regulated by MNNG-treatment, of which expression also decreased in the cancer cells. (C) PPIs between the DEGs, of which expression increased exclusively in the AGS and MKN45 cancer cell lines. (D) PPIs between the DEGs, of which expression decreased exclusively in the AGS and MKN45 cancer cell lines. Each circle indicates a protein and the color inside each circle indicates a pathway from the KEGG pathway database wherein functional roles of the protein are found. The color of the strings connecting each circle indicates known interactions between two proteins (Blue: from curated databases, Red: experimentally determined).
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