Relation between alloantibody development and several variables in the studied multi-transfused patients with β-thalassemia major
| Variables | Non-alloimmunized | Alloimmunized | |
|---|---|---|---|
| Number of patients | 192 | 12 | - |
| Age/years | 0.243 | ||
| Mean±SD (range) | 11±5 (2∼27) | 12±3 (9∼16) | |
| Sex | 0.293 | ||
| Male | 98 (51) | 8 (66.7) | |
| Female | 94 (49) | 4 (33.3) | |
| ABO blood groups | 0.920 | ||
| A | 84 (44) | 6 (50) | |
| B | 42 (22) | 2 (17) | |
| O | 62 (32) | 4 (33) | |
| AB | 4 (2) | 0 (0) | |
| RhD blood group | 0.174 | ||
| Positive | 188 (98) | 11 (92) | |
| Negative | 4 (2) | 1 (8) | |
| Age at first transfusion | 0.042 | ||
| <2 years | 177 (92.2) | 9 (75) | |
| ≥2 years | 15 (7.8) | 3 (25) | |
| Frequency of blood transfusion/Years | 0.893 | ||
| <12 units/year | 14 (7.3) | 1 (8.3) | |
| ≥12 units/year | 178 (92.7) | 11 (91.7) | |
| Total number of transfused RBC units | 0.878 | ||
| Mean±SD (range) | 197±204 (14∼790) | 206±73 (108∼384) | |
| History of transfusion reaction | 0.003 | ||
| Positive | 90 (47) | 11 (91.7) | |
| Negative | 102 (53) | 1 (8.3) | |
| Splenectomy | 0.114 | ||
| Yes | 42 (22) | 5 (41.6) | |
| No | 150 (78) | 7 (58.4) | |
