The Korean Journal of Clinical Laboratory Science : eISSN 2288-1662 / pISSN 1738-3544

Table. 2.

Table. 2.

The significant association results of SNPs in the MACROD2 gene with blood pressures and hypertension in the KARE

No.SNPMinor alleleMAFFunctionHypertension (controls 4450: cases 1968)SBPDBP




CasesControlsOR (95%CI)Add PBeta±seAdd PBeta±seAdd P
1rs6110206T0.3670.382intron0.90 (0.83∼0.98)0.019-0.26±0.270.325-0.17±0.180.342
2rs6042613T0.3670.383intron0.91 (0.83∼0.99)0.024-0.27±0.270.304-0.15±0.180.401
3rs17263597C0.3920.414intron0.91 (0.84∼0.99)0.031-0.39±0.260.133-0.21±0.180.232
4rs1998238C0.3960.419intron0.91 (0.84∼0.99)0.034-0.43±0.260.103-0.25±0.180.164
5rs2208453T0.3940.413intron0.91 (0.84∼0.99)0.031-0.39±0.260.141-0.20±0.180.261
6rs994567T0.3930.413intron0.92 (0.84∼1.00)0.038-0.36±0.260.166-0.19±0.180.282
7rs6110305C0.2320.248intron0.90 (0.82∼0.99)0.028-0.43±0.300.161-0.01±0.210.951
8rs16996211T0.1610.187intron0.85 (0.76∼0.95)3.1×10-3-0.75±0.330.024-0.59±0.230.010
9rs6034240C0.1220.135intron0.83 (0.74∼0.94)4.2×10-3-0.62±0.380.098-0.61±0.260.018
10rs17705904C0.0300.025intron1.30 (1.01∼1.67)0.0381.21±0.800.1330.75±0.550.167
11rs6080048T0.2600.247intron1.10 (1.00∼1.21)0.0470.48±0.300.1090.31±0.200.128
12rs6110847T0.2560.243intron1.10 (1.01∼1.21)0.0380.50±0.300.0980.32±0.200.119
13rs6080057G0.2500.238intron1.11 (1.01∼1.22)0.0360.47±0.300.1160.28±0.200.171
14rs6080069A0.2520.239intron1.12 (1.02∼1.23)0.0220.50±0.300.0960.28±0.200.168
15rs6074984C0.2550.243intron1.12 (1.02∼1.23)0.0240.51±0.300.0870.29±0.200.158
16rs775109T0.1930.172intron1.13 (1.02∼1.26)0.0200.47±0.340.1620.33±0.230.148

Abbreviations: beta, regression coefficient; CI, confidence interval; KARE, Korean association resource; MAF, minor allele frequency; OR, odds ratio; se, standard error; SNP, single nucleotide polymorphism; Controls (normotensive), SBP<120 mmHg and DBP<80 mmHg; Cases (hypertensive), SBP=140 mmHg and/or DBP=90 mmHg and/or antihypertensive medication. Statistically significant values (P <0.05) are indicated in bold and underline.

Korean J Clin Lab Sci 2019;51:57-63 https://doi.org/10.15324/kjcls.2019.51.1.57
© 2019 Korean J Clin Lab Sci