The Korean Journal of Clinical Laboratory Science : eISSN 2288-1662 / pISSN 1738-3544

Fig. 1.

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Fig. 1.

Schematic representation of mesenchymal stem cell (MSC). MSCs can be obtained from various sources in the body, including bone marrow, peripheral blood, adipose tissue, placenta, umbilical cord, and umbilical cord blood. They have the ability to differentiate into myocytes, chondrocytes, fibroblasts, astrocytes, adipocytes, and osteocytes under specific in vitro conditions. In general, MSCs are positive for CD29 (β1-integrin), CD44 (HCAM), CD73 (5’-nucleotidase), CD90 (Thy-1), and CD105 (endoglin), but negative for CD14, CD31 (PECAM-1), CD34, CD45, and CD133 (prominin-1). Soluble factors secreted from MSCs including transforming growth factor-β1 (TGF- 1), hepatocyte growth factor (HGF), nitric oxide (NO), prostaglandin E2 (PGE2), and indoleamine 2,3-dioxygenase (IDO) affect various subsets of lymphocytes including CD8+ cytotoxic T-lymphocytes (CTL), regulatory T-lymphocytes (Treg), B-lymphocytes, natural killer (NK) cells, gamma delta T-cells, and CD4+ helper T-lymphocytes (Th).

Korean J Clin Lab Sci 2018;50:391-8
© 2018 Korean J Clin Lab Sci