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Fig. 2.

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Fig. 2.

Aschheim-Zondek test. Left: non-pregnant; Right: pregnant. German scientists Selmar Aschheim and Bernhard Zondek developed the very first bioassay pregnancy test, known as the “A-Z test”, which identified the presence of hCG in urine. To test for pregnancy, a woman’s urine was subcutaneously injected into an immature rat or mouse. In the case of pregnancy, the rat would show an estrous reaction (be in heat) despite its immaturity and enlargement of the uterine horns, luteinization in the ovary and hemorrhage were also observed [16].

Korean J Clin Lab Sci 2018;50:382-90 https://doi.org/10.15324/kjcls.2018.50.4.382
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